I am the most powerful hormone in the human body. I am secreted
by fat cells (white adipose tissues). If you want to understand the
functioning of the human body, you have to understand me and my
I am necessary for survival.
I respond to specific patterns and I am fundamental in regulating
your body rhythms. I am the key to understanding the pathway to type
I am responsible for keeping fat from being deposited on vital
organs, such as spleen, liver, pancreas, and heart.
For every system in your body to function properly, I must
function properly; my role is to oversee the endocrine system, the
immune system, the digestive system, and your metabolism from its
entirety down to the metabolism of each individual cell. I control
food intake, fat storage, and I either allow or restrict energy.
If I am in abundance too long (over-abundance), the human body
becomes resistant to me, inflammation sets in, and I reinforce an
environment that can lead to heart disease, cancer, and a host of
If your bran is insensitive/resistant to me, your body is
insensitive/resistant to insulin. Thus, I am all about balance and
As we age, resistance to me becomes an even bigger issue and
adrenaline resistance can also become an issue, which can lead to
I am the most important hormone helping the brain determine
energy usage in the body.
I am all about survival.
However, in an alcoholic, because of an overabundance of me and a
subsequent resistance to me, cravings for alcohol are felt by the
individual as if they were cravings for food and sustenance.
In an individual without resistance to me, the partaking of
alcohol lowers my release causing the individual to overeat. If this
continues on a steady basis, the individual will gain weight and
become resistant to me.
When my levels are elevated, I set in motion a cascading effect
of immune cell activity, first stimulating the release and actions
of TNF (tumor necrosis factor). In its normal capacity, TNF will
take care of incipient tumors; in over abundance, TNF is highly
inflammatory. This can lead to a host of degenerative illnesses,
auto-immune responses, and aging, all of which stresses out the
body. When stressed, NF kappaB (a regulatory part of the cells
immune system) inside the cells is activated causing further
inflammation in the body.
However, when I am regulated and recognized, the proper amount of
me in the brain controls how tissues grow in the body (even how a
fetus grows in the mother) and I protect and regulate dopamine
levels in the brain and prevent Parkinsonís disease. In fact, I
protect the brain from a host of damage that could be cause by drugs
and other toxins.
It is because of me that white adipose tissues (fat) is no longer
just fat but rather, as scientists now recognize it, is part of your
When the brain recognizes me, in higher levels, I tell the body
it is full; whereas in lower levels, I tell the body it is hungry.
All of this happens through the subconscious.
Now get this.
I was discovered in 1994.
Who am I?
I am leptin.
Leptin has been called the "weight loss" hormone, but as you can
see, it is so much more. However, let me tell you about a special
It is called an
This little critter had an appetite like no other mouse. It just
could not stop eating. If mixed in with normal mice, it quickly
grows to three times the size of the other mice.
It was discovered that the ob/ob mouse has a mutated gene.
Because that mutation, it does not synthesize leptin. When given
leptin, the ob/ob mice started eating normal amounts of food. This
is why leptin has been labeled the weight loss hormone; when it's
low, we are stimulated to eat; when it is high, we stop eating.
Scientists quickly hypothesized that our obesity epidemic must be
caused by a lack of leptin. Wrong.
What scientists quickly discovered was that our obese population
was FULL of leptin. The problem was their brains just didn't know
it. They had become resistant/insensitive to leptin.
And then came the "aha moment:" if your brain is insensitive to
leptin, your body is insensitive to insulin.
Leptin resistance causes fat and fat causes leptin resistance.
Which came first? The chicken or the egg?
Here is an article that took well over a year to research and
write. I hope you'll enjoy it, but even more, I hope you'll learn
from it: The Disease of Our Time.
Mastering Leptin: Your Guide to Permanent Weight Loss and Optimum Health (Third Edition)
dose-response study in obese (ob/ob) and lean (+/?) mice.